图表内容
24.mRNA分子结构
5'cap
Poly (A)tail
Prevents the rapid degradation
Length influences protein
of mRNA by exonucleases
expression
Mediates binding to elF4E
ORF
Prevents decapping and
Prevents innate immune sensing
Codon composition
mRNA degradation
affects translation
Masking affects translation
-0(m7G(5')pppN1pN2p)
efficiency
5'
5'UTR
ORF
CAP
3'UTR
o-2 (m7G(5')pppN1mpN2mp
5'UTR
3'UTR
B-globin 5'-UTRs
a-globin 3'-UTRs stabilize mRNA
enhance translation
B-globin 3'-UTRs enhance translation
efficiency
efficiency
Adenylate-uridylate-rich elements in
3'-UTRs degrade mRNA and reduces
protein expression
源：Pharmaceutics
东亚前海证苏研究所
