图表内容
表1：TCE双抗的结构
CD3 targeting arm
Tumor targeting arm
Binding epitope of
Epitope/affinity of tumor
anti-CD3
antigen binding
Binding affinity of
Ligand/soluble target
anti-CD3
competition
Species cross-
On-target
off-tumor
reactivity
specificity
Fc domain
FcRn binding for half-life
extension
Silencing variants to
eliminate FcR binding
科来源：Perspective.:Designing T-Cell Engagers With Better Therapeutic Windows
国盛证券研究所
